The de-escalation antibiotics promote optimal bactericidal effect when drug concentrations are maintained above the minimum inhibitory concentration (minimum inhibitory concentration - MIC). The time that concentration of drug above the MIC is the pharmacokinetic parameters specific to time-dependent antibiotic. Normally, concentrations are maintained at 2 to 4 times the MIC during the time between 2 times the drug. Area under the curve (AUC) is limited by the axis coordinates and line performers of the drug concentration-time. ratio AUC / MIC is applicated of time-dependent bactericidal antibiotic. For this drug concentration further does not create a higher bactericidal effect, Furthermore, they are not or only creates the effect of antibiotics (postantibiotic effect - PAE) at least. most antibiotic are in this group, for example: beta-lactam, vancomycin, Metronidazole, quinolone, Macrolide.

the escalation antibiotic will depend achieve effective antimicrobial concentrations higher than the increase medication. Moreover these drugs have the antimicrobial effect (PAE) Concentration-dependent effects can be maintained even after bactericidal drug concentrations decrease below the minimum inhibitory concentration (MIC). Effect of these antibiotics were determined by the maximum concentration (peak concentration) and area under the curve concentration-time (AUC). For this group of drugs, the concentration necessary to obtain optimal bactericidal effect not less than 10 times the MIC. for example: Aminoglycoside.