20 MCQ of real women of 46XX, Thelarche, Pubarche, Menarche…
1. What is the typical female karyotype?
A. 46XY
B. 45X0
C. 46XX
D. 47XXY
✅ Answer: C. 46XX
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🧬 2. Thelarche refers to:
A. First period
B. Pubic hair growth
C. Breast development
D. Hip widening
✅ Answer: C. Breast development
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🧬 3. What is the first visible sign of puberty in most females?
A. Menarche
B. Pubarche
C. Growth spurt
D. Thelarche
✅ Answer: D. Thelarche
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🧬 4. What is pubarche?
A. First ovulation
B. Start of pubic hair growth
C. Growth of underarm hair
D. Breast enlargement
✅ Answer: B. Start of pubic hair growth
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🧬 5. Menarche usually occurs after which of the following events?
A. Breast development begins
B. Height stops increasing
C. Body odor appears
D. Voice deepens
✅ Answer: A. Breast development begins
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🧬 6. What hormone mainly drives thelarche?
A. Testosterone
B. Progesterone
C. Estrogen
D. Cortisol
✅ Answer: C. Estrogen
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🧬 7. At what Tanner stage does menarche typically occur?
A. Stage I
B. Stage II
C. Stage III
D. Stage IV
✅ Answer: D. Stage IV
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🧬 8. Which hormone is responsible for ovulation and menarche?
A. FSH
B. LH
C. GnRH
D. All of the above
✅ Answer: D. All of the above
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🧬 9. What is the average age of menarche worldwide?
A. 8
B. 10
C. 12
D. 15
✅ Answer: C. 12
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🧬 10. Which condition may delay menarche?
A. High body fat
B. Athletic training
C. Sleep disorders
D. Myopia
✅ Answer: B. Athletic training
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🧬 11. Which structure produces estrogen in the ovaries?
A. Follicle
B. Corpus luteum
C. Theca cells
D. Granulosa cells
✅ Answer: D. Granulosa cells
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🧬 12. What gene is absent in typical 46XX individuals?
A. SRY gene
B. FOXP2
C. BRCA1
D. CFTR
✅ Answer: A. SRY gene
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🧬 13. A girl with thelarche but no pubarche might have:
A. Androgen insensitivity
B. Turner syndrome
C. Premature adrenarche
D. Delayed puberty
✅ Answer: A. Androgen insensitivity
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🧬 14. In females, which hormone surge causes ovulation?
A. FSH
B. LH
C. Estrogen
D. Progesterone
✅ Answer: B. LH
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🧬 15. Which gland starts the hormonal cascade for puberty?
A. Thyroid
B. Pituitary
C. Hypothalamus
D. Adrenal
✅ Answer: C. Hypothalamus
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🧬 16. What physical change follows pubarche?
A. Acne
B. Voice deepening
C. Testicular growth
D. Facial hair
✅ Answer: A. Acne
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🧬 17. When does the growth spurt typically occur in girls?
A. After menarche
B. Before thelarche
C. Between thelarche and menarche
D. After pubarche
✅ Answer: C. Between thelarche and menarche
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🧬 18. What is the typical hormonal pattern in early female puberty?
A. High cortisol, low FSH
B. GnRH → FSH & LH → Estrogen
C. Estrogen → GnRH → LH
D. Testosterone → Progesterone
✅ Answer: B. GnRH → FSH & LH → Estrogen
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🧬 19. Which of the following is NOT part of normal female puberty?
A. Breast budding
B. Growth of facial beard
C. Onset of menstruation
D. Widening of hips
✅ Answer: B. Growth of facial beard
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🧬 20. Which phase follows menarche in the menstrual cycle?
A. Ovulation
B. Follicular phase
C. Luteal phase
D. Menopause
✅ Answer: B. Follicular phase