Hypocalcemia is a common condition characterized by a net loss of calcium from extracellular fluid in greater quantities than can be replaced by the intestine or bone. Hypocalcemia is caused by a number of clinical entities and often presents with signs of generalized neuromuscular irritability including paresthesia, muscle cramps, laryngospasm, tetany, and seizures. This neuromuscular instability can also be displayed through the elicitation of Chvostek’s sign and Trousseau’s sign (Sidebars). Both Chvostek’s sign and Trousseau’s sign are timehonored physical predictors that are well- chronicled in medical history and frequently associated with hypocalcemia.