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Ðề tài: Tội nghiệp virus viêm gan B...

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    Default Tội nghiệp virus viêm gan B...

    Chủ Đề: Default Tội nghiệp virus viêm gan B...

    ►Lượt Xem: 4780 ►Trả Lời: 0
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    ►Ngày Gửi: 14-06-11 ►Đánh Giá: Sao

    Chúng ta nghĩ sai cho HBV rồi, tổn thương gan sau nhiễm HBV không phải do HBV đâu, là do hệ miễn dịch của ta đấy.

    Under ordinary circumstances, none of the hepatitis viruses is known to be directly cytopathic to hepatocytes.
    For HBV, the existence of inactive hepatitis B carriers with normal liver histology and function suggests that the virus is not directly cytopathic. The fact that patients with defects in cellular immune competence are more likely to remain chronically infected rather than to clear HBV is cited to support the role of cellular immune responses in the pathogenesis of hepatitis B–related liver injury. The model that has the most experimental support involves cytolytic T cells sensitized specifically to recognize host and hepatitis B viral antigens on the liver cell surface. Laboratory observations suggest that nucleocapsid proteins (HBcAg and possibly HBeAg), present on the cell membrane in minute quantities, are the viral target antigens that, with host antigens, invite cytolytic T cells to destroy HBV-infected hepatocytes.

    During HBV infection, the host immune response causes both hepatocellular damage and viral clearance. Although the innate immune response does not play a significant role in these processes, the adaptive immune response, particularly virus-specific cytotoxic T lymphocytes (CTLs), contributes to most of the liver injury associated with HBV infection. CTLs eliminate HBV infection by killing infected cells and producing antiviral cytokines, which are then used to purge HBV from viable hepatocytes. Although liver damage is initiated and mediated by the CTLs, antigen-nonspecific inflammatory cells can worsen CTL-induced immunopathology, and platelets activated at the site of infection may facilitate the accumulation of CTLs in the liver.





    Harrison's 17th
    http://en.wikipedia.org/wiki/Hepatitis_B
    thay đổi nội dung bởi: Ways, 14-06-11 lúc 11:58 PM
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