Amyloidosis is a rare, chronic disease resulting in the accumulation of an abnormal fibrillar scleroprotein (amyloid), which infiltrates body organs and soft tissues. Amyloidosis is classified in two ways, based on histologic findings: perireticular type, which affects the inner coats of blood vessels, and pericollagen type, which affects the outer coats of blood vessels and also involves the parenchyma.

Amyloidosis produces dysfunction of the kidneys, heart, GI tract, peripheral nerves, and liver.

Liver: Hepatic amyloidosis is rare and usually coexists with other forms of this disease. It generally produces liver enlargement(Hepatomegaly
), often with azotemia, anemia, albuminuria and, rarely, jaundice.