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Ðề tài: The Complement System

  1. #1
    lightanddark
    Guest

    Thumbs up The Complement System

    Chủ Đề: Thumbs up The Complement System

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    ►Ngày Gửi: 02-06-09 ►Đánh Giá: Sao

    The Complement System
    thay đổi nội dung bởi: lightanddark, 02-06-09 lúc 10:18 PM

  2. #2
    lightanddark
    Guest

    Thumbs up The Complement System


    The Complement System



    innate defense functions
    trigger inflammation
    attract phagocytes
    opsonize antigens
    cause cell lysis
    activate naïve B-lymphocytes
    remove immune complexes



    the classical pathway
    antibody-dependent
    proteins of the classical pathway
    C1
    6 molecules of C1q
    2 molecules of C1r
    2 molecules of C1s

    C3
    C5

    Ag-Ab complex activates C1

    animation showing the assembly of C1 during the classical pathway


    animation showing the assembly of C3 convertase

  3. #3
    lightanddark
    Guest

    Thumbs up The Complement System


    animation showing the cleavage of C3 and the formation of C5 convertase


    opsonization and phagocytosis [C3b]

    CR1 receptors



    inflammation [C5a]

    the MAC and lysis [C5b6789n]

    animation showing the formation of the MAC





    agglutination

    Type III hypersensitivity reaction

    • rheumatoid arthritis
    • subacute bacterial endocarditis
    • immune complex glomerulonephritis
    • systemic lupus erythematosus
    • Arthus reaction
    • Farmer’s lung
    • polyarteritis nodosa


    viral neutralization

    chemotaxis [C5a]

    animation showing the benefits of C5a and C3b

    basophil/mast cell activation [C3a, C4a, C5a]


  4. #4
    lightanddark
    Guest

    Thumbs up The Complemnt System


    the lectin pathway

    mannan-binding lectin (MBL)–dependent

    proteins of the lectin pathway
    MASP1
    MASP2

    C4 & C2 cleaved

    animation of the lectin pathway


    the alternative pathway

    animation of the alternative pathway and formation of C3 convertase


    antibody-independent



    proteins of the alternative pathway

    C3
    C3b
    C3i
    B
    D
    H
    I
    P (properdin)


  5. #5
    lightanddark
    Guest

    Thumbs up The Complement System


    animation of the formation of C5 convertase.


    large polysaccharides react with factors B and D

    C3bB
    C3bBb

    formation of activation product that activates C3
    Bb
    C3bBbP

    regulation of complement activity
    factor H
    factor I
    C1 inhibitor (C1INH)



    complement receptors
    CR1


    CR2
    CR3
    CR4


  6. #6
    lightanddark
    Guest

    Thumbs up The Complement System


    disorders of the complement system


    C3 deficiency
    C2 deficiency
    immune complex disorders
    systemic lupus erythematosus (SLE)

    C9 deficiency
    C1INH deficiency
    hereditary angioneurotic edema (HANE)
    decay accelerating factor (DAF) deficiency
    paroxysmal nocturnal hemoglobinura (PNH)





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