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For many years the standard therapy for hypercalciuria was dietary calcium restriction. However, recent studies have shown that low-calcium diets increase the risk of incident stone formation. Low-calcium diets may lead to stone formation by reducing the amount of calcium to bind oxalate in the intestine, thereby increasing urine oxalate levels. However, the mechanism by which a low-calcium diet increases stone risk has not been clearly defined. In addition, hypercalciuric stone formers have reduced bone mineral density and an increased risk of fracture compared to the non-stone-forming population. Low calcium intake likely contributes to the low bone mineral density. A 5-year prospective trial compared the efficacy of a low-calcium diet to a low-protein, low-sodium, normal-calcium diet in preventing stone recurrence in male calcium stone formers. The group on the low-calcium diet had a significantly greater rate of stone relapse. Low-calcium diets are of unknown efficacy in preventing stone formation and carry a long-term risk of bone disease in the stone-forming population. Low-sodium and low-protein diets are a superior option in stone formers. - Nephrolithiasis, Harrison's 17th.