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Ðề tài: Bacteroides fragilis

  1. #1
    hoanganh_89
    Guest

    Post Bacteroides fragilis

    Chủ Đề: Post Bacteroides fragilis

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    ►Ngày Gửi: 10-12-09 ►Đánh Giá: Sao

    1. Some notices about anaerobic bacteria:
    - energy from fermentation reactions
    - no cytochrome system --> do not use oxygen for growth and metabolism, and oxygen toxicity with presence of oxygen in environment
    - small amounts of (or without) catalase and superoxide dismutase (/peroxidases )( ~ H2O2)
    - example: Bacteroides and Clostridium species

    2. Bacteroides: (fragilis, …)
    - Gram (-), no ondontoblast
    - normal inhabitants the bowel and other sites (normal flora)
    - infections + contamination of tissue (ex: colon)
    - Infections: combinations of bacteria that function in synergistic pathogenicity
    - the capsular polysaccharides of bacteroides are important virulence factors
    - weak endotoxic activity
    - Passive transfer of antibodies from an immune animal to a nonimmune animal is protective against bacteroides

    picture here...............

    3. Clinical signs: suggesting possible infection with anaerobes include the following:

    (1) Foul-smelling discharge (due to short-chain fatty-acid products of anaerobic metabolism).
    (2) Infection in proximity to a mucosal surface (anaerobes are part of the normal flora).
    (3) Gas in tissues (production of CO2 and H2).
    (4) Negative aerobic cultures.

    4. Nuôi cấy:

    + complex media : Schaedler blood agar, brain-heart infusion agar
    + selective complex medium: containing kanamycin
    identifying anaerobes: Colony morphology, pigmentation, and fluorescence

    5. Treatment:

    - Clindamycin is preferred for infections above the diaphragm
    - metronidazole
    - cephalosporins, and piperacillin

    From : Medical Microbiology, 24th - Jawetz, Melnick, & Adelberg's
    More : Wikipedia




    Normal flora?

    The term "normal microbial flora" (VK chí bình thường) denotes the population of microorganisms that inhabit the skin and mucous membranes of healthy normal persons.
    The skin and mucous membranes always harbor a variety of microorganisms that can be arranged into two groups:

    (1) The resident flora consists of relatively fixed types of microorganisms regularly found in a given area at a given age; if disturbed, it promptly reestablishes itself.
    (2) The transient flora consists of nonpathogenic or potentially pathogenic microorganisms that inhabit the skin or mucous membranes for hours, days, or weeks; it is derived from the environment, does not produce disease, and does not establish itself permanently on the surface. Members of the transient flora are generally of little significance so long as the normal resident flora remains intact. However, if the resident flora is disturbed, transient microorganisms may colonize, proliferate, and produce disease.



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    thay đổi nội dung bởi: hoanganh_89, 10-12-09 lúc 11:39 PM

  2. #2
    hoanganh_89
    Guest

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